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Dr. Samantha "Sam" Waters is the main character on the TV series Profiler. The actress Ally Walker who played Samantha Waters, had a guest appearance as her Profiler character in The Pretender episode End Game. This led to the first of The Pretender/Profiler crossover episodes.

Best referred to as Sam Waters, is a forensic psychologist who has a tragic past with serial killer known only as Jack of All Trades.

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